The genetic disease, Hypoascorbemia. A fresh approach to an ancient disease and some of its medical implications.

@article{Stone1967TheGD,
  title={The genetic disease, Hypoascorbemia. A fresh approach to an ancient disease and some of its medical implications.},
  author={Irwin Stone},
  journal={Acta geneticae medicae et gemellologiae},
  year={1967},
  volume={16 1},
  pages={
          52-62
        }
}
  • I. Stone
  • Published 1967
  • Medicine, Biology
  • Acta geneticae medicae et gemellologiae
It has been recently shown that the human requirement for exogenous ascorbic acid and the disease, scurvy, are the result of a typical genetic disease syndrome caused by a defect on the gene controlling the synthesis of the enzyme protein, L-gulonolactone oxidase. The lack of this active enzyme in the human liver prevents Man from producing his own ascorbic acid; a synthesis which is regularly carried out by nearly all other mammals. This genetic disease has been named, Hypoascorbemia. This new… 
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The Genetics of Scurvy and the Cancer Problem
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A brief historical look into how half-truths and misorientations have lulled an uncritical Medicine into such a state of euphoria about scurvy that a large proportion of physicians are unable to treat it.
An Orthomolecular Theory of Human Health and Disease
TLDR
The evidence indicates that ascorbate insufficiency is the most important cause of poor health, with the blood level of apopro-tein(a) also contributing, as well as insufficiencies in some other vitamins and some endogenous substances.
The Cure from Nature: The Extraordinary Anticancer Properties of Ascorbate (Vitamin C)
TLDR
Vitamin C (sodium ascorbate) in high doses, administered by intravenous route, is safe, has minimal contraindications, improves the quality of life of patients, and is highly selective for cancer cells.
Deficiency of vitamin C in South Asia.
TLDR
The high proportion of individuals with low levels of vitamin C in Pakistani, Indian, Malay and Chinese populations compared to most Western populations might explain higher rates of cardiovascular disease and cancer among South Asians.
Lognormal Model for Ascorbic Acid Requirements in Man
TLDR
The purpose of this paper is to show that the four affirmative studies mentioned above can be made to fit very neatly a log-normal distribution with large variance and will lend support to the conclusion of Williams and Deason mentioned above and to the computations by Bourne, Pauling, and Stone of the typical daily amounts of vitamin C required for full health.
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  • I. Stone
  • Biology, Medicine
    Acta geneticae medicae et gemellologiae
  • 1966
TLDR
The replacement of the present vitamin C theory regarding the etiology of scurvy by this genetic concept gives important new viewpoints to the quantitative aspects of ascorbic acid in human physiology and also provides new rationales for the use of high levels of as Corinthian acid in normal physiology and in the therapy of clinical entities other than scorvy.
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TLDR
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TLDR
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TLDR
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TLDR
Tests on the enzymes required for the synthesis of ascorbic acid within animals could prove of value in deducing which ancestor of Man lost this important biochemical system and at what point in Time it was lost.
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