The genetic determinants of smoking.

  title={The genetic determinants of smoking.},
  author={Vikas Batra and Ashwin A. Patkar and Wade H. Berrettini and Stephen Weinstein and Frank T. Leone},
  volume={123 5},
Dependence on tobacco, like many other drug dependencies, is a complex behavior with both genetic and environmental factors contributing to the variance. The heritability estimates for smoking in twin studies have ranged from 46 to 84%, indicating a substantial genetic component to smoking. Candidate gene studies have detected functional polymorphisms in genes coding for the cytochrome P450 enzymes, and variations in these genes that lead to more rapid nicotine metabolism have been implicated… CONTINUE READING

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