The genetic contribution to non-syndromic human obesity

  title={The genetic contribution to non-syndromic human obesity},
  author={A. Walley and Julian E. Asher and P. Froguel},
  journal={Nature Reviews Genetics},
  • A. Walley, Julian E. Asher, P. Froguel
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Genetics
  • The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan… CONTINUE READING
    378 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    The genetics of human obesity
    • 71
    • PDF
    Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis
    • 2
    Genetics in obesity
    • PDF
    Obesity in single gene disorders.
    • 3
    Genetics of Childhood Obesity
    • 57
    • PDF
    [Genetic determinants of obesity. Current issues].
    • 5
    Heritability of body weight: moving beyond genetics.
    • 22


    Genetics of human obesity.
    • K. Clément
    • Biology, Medicine
    • The Proceedings of the Nutrition Society
    • 2005
    • 460
    FTO: the first gene contributing to common forms of human obesity
    • R. Loos, C. Bouchard
    • Biology, Medicine
    • Obesity reviews : an official journal of the International Association for the Study of Obesity
    • 2008
    • 257
    Variation in FTO contributes to childhood obesity and severe adult obesity
    • 1,342
    Assessment of genetic linkage and parent-of-origin effects on obesity.
    • Y. Guo, H. Shen, +7 authors H. Deng
    • Geography, Medicine
    • The Journal of clinical endocrinology and metabolism
    • 2006
    • 34
    • PDF
    The human obesity gene map: the 2005 update.
    • 890
    Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.
    • 50
    • PDF