The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models.

@article{Belzung2001TheGB,
  title={The genetic basis of the pharmacological effects of anxiolytics: a review based on rodent models.},
  author={Catherine Belzung},
  journal={Behavioural pharmacology},
  year={2001},
  volume={12 6-7},
  pages={
          451-60
        }
}
Anxiolytic drugs exert their pharmacological actions by binding to molecular targets, such as benzodiazepine receptors or 5-hydroxytryptamine (5-HT) receptors. Specific genes encode these receptors, or the subunits of which they are formed. Therefore, genetic factors may influence strongly the ability of anti-anxiety agents to produce their behavioural effects. The literature on this subject is reviewed here, with emphasis on data derived from studies with rodents. We present in a critical way… CONTINUE READING

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