The genetic basis of infertility in men.

  title={The genetic basis of infertility in men.},
  author={Shalender Bhasin and Con Mallidis and Kun Ma},
  journal={Bailliere's best practice & research. Clinical endocrinology & metabolism},
  volume={14 3},
Subfertility in men is a heterogeneous syndrome, its pathophysiology remaining unknown in the majority of affected men. A large number of genes and loci are associated with sterility in experimental animals, but the human homologues of most of these genes have not been characterized. A British study suggested that, in a large proportion of men with idiopathic infertility, the disorder is inherited as an autosomal recessive trait; this provocative hypothesis needs confirmation. Because normal… CONTINUE READING