The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation.

@article{Parkinson1997TheGB,
  title={The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation.},
  author={Eric Kenneth Parkinson and Robert Frank Newbold and W. Nicol Keith},
  journal={European journal of cancer},
  year={1997},
  volume={33 5},
  pages={727-34}
}
Normal human keratinocytes have a finite replicative lifespan which culminates in senescence. Chromosomal telomere length may act as a mediator of replicative senescence, signalling cell cycle arrest in G1 when one or more telomeres become too short. Telomeric attrition in normal keratinocytes may be due to inadequate levels of telomerase activity and… CONTINUE READING