The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

@article{Zhang2012TheGB,
  title={The genetic basis of early T-cell precursor acute lymphoblastic leukaemia},
  author={Jinghui Zhang and Li Chao Ding and Linda Holmfeldt and Gang Wu and Sue L. Heatley and Debbie Payne-Turner and John W. Easton and Xiang Chen and Jianmin Wang and Michael C Rusch and Charles Lu and Shann-Ching Chen and Lei Wei and J. Racquel Collins-Underwood and Lei Qiao and Kathryn G. Roberts and Stanley B Pounds and Anatoly Ulyanov and Jared B Becksfort and Pankaj Gupta and Robert Huether and Richard W. Kriwacki and Matthew Austin Parker and Daniel J. McGoldrick and David Zhao and Daniel P. Alford and Stephen Espy and Kiran C. Bobba and Guangchun Song and Deqing Pei and Cheng Cheng and Stefan D. Roberts and Michael I. Barbato and Dario Campana and Elaine Coustan-Smith and Sheila Shurtleff and Susana C. Raimondi and M Mieke Kleppe and Jan Cools and Kristin Ammon Shimano and Michelle L Hermiston and Sergei R. Doulatov and Kolja Eppert and Elisa Laurenti and Faiyaz Notta and John E Dick and Giuseppe Basso and Stephen P Hunger and Mignon L Loh and Meenakshi Devidas and Brent M. Wood and Stuart S. Winter and Kimberley P. Dunsmore and Robert F Sir Fulton and Lucinda L. Fulton and Xin Hong and Christopher C. Harris and D. James Dooling and Kerri Ochoa and Kimberly J Johnson and John C. Obenauer and William E. Evans and Ching-Hon Pui and Clayton W. Naeve and Timothy J. Ley and Elaine R. Mardis and Richard K. Wilson and James R. Downing and Charles G Mullighan},
  journal={Nature},
  year={2012},
  volume={481},
  pages={157-163}
}
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell acute lymphoblastic leukaemia cases. ETP ALL was characterized by activating mutations in genes regulating cytokine receptor and RAS signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF), inactivating lesions disrupting… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 457 CITATIONS, ESTIMATED 42% COVERAGE

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

  • The Journal of experimental medicine
  • 2018
VIEW 9 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma.

  • American journal of cancer research
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 71 Highly Influenced Citations

  • Averaged 55 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

results from a comprehensive genetic and clinical analysis from the AML study group

Gaidzik, V. I. et al. RUNX1 mutations in acute myeloid leukemia
  • J. Clin. Oncol. 29, 1364–1372
  • 2011

Similar Papers

Loading similar papers…