The genetic basis of cancer of the kidney.

@article{Linehan2003TheGB,
  title={The genetic basis of cancer of the kidney.},
  author={W. Marston Linehan and M. M. Walther and Berton Zbar},
  journal={The Journal of urology},
  year={2003},
  volume={170 6 Pt 1},
  pages={
          2163-72
        }
}
PURPOSE The types of epithelial renal tumors are clear cell, types I and II papillary, chromophobe and oncocytoma. We identified the genetic basis of these different types of kidney cancer to provide better methods for early diagnosis of this disease as well as provide the foundation for the development of molecular therapeutic approaches. MATERIALS AND METHODS To identify the genetic basis of kidney cancer we studied families with an inherited predisposition to kidney cancer. Families in… 
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Identification of genetic basis of hereditary carcinomas provides opportunity for targeted therapy of metastatic sporadic renal cell carcinoma and allows for preservation of renal function despite the need for repeat surgical interventions.
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  • Medicine, Biology
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  • 2015
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Hereditary leiomyomatosis and renal cell cancer: an unusual and aggressive form of hereditary renal carcinoma
TLDR
Papillary type 2 RCC described in the context of hereditary leiomyomatosis and renal cell cancer (HLRCC), an autosomal dominant syndrome attributable to a mutation in the fumarate hydratase (FH) gene on chromosome 1.
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