The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery
- BiologyFront. Neurosci.
These complementary large-scale efforts are joining forces to uncover the full range of genetic variation and environmental risk factors for TS, holding great promise for identifying definitive TS susceptibility genes and shedding light into the complex pathophysiology of this disorder.
Candidate Genes and Pathways Associated with Gilles de la Tourette Syndrome—Where Are We?
- Psychology, BiologyGenes
To understand the genetic components of GTS etiopathology, an extensive review of the literature is conducted, compiling the candidate susceptibility genes identified through various genetic approaches.
The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods
- BiologyEuropean Child & Adolescent Psychiatry
The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent–child trios with non-familial tics.
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research
- Psychology, BiologyFront. Neurosci.
It is proposed that some general epigenetic mechanisms seen in other neuropsychiatric disorders may also play a role in the pathogenesis of Tourette Syndrome.
Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene.
- Biology, PsychologyJournal of psychiatric research
Gilles de la Tourette syndrome
- Psychology, MedicineNature Reviews Disease Primers
Future research that integrates clinical and neurobiological data, including neuroimaging and genetics, is expected to reveal the pathogenesis of GTS at the neural circuit level, which may lead to targeted interventions.
The Genetics of Gilles de la Tourette Syndrome: a Common Aetiological Basis with Comorbid Disorders?
- Psychology, BiologyCurrent Behavioral Neuroscience Reports
Evidence pointing to a shared genetic basis among TS, OCD, ADHD and ASD is summarized and discussed, highlighting the importance of thinking across diagnostic categories when attempting to understand the neurobiology of neurodevelopmental phenotypes.
Association of the AADAC gene and Tourette syndrome in a Han Chinese cohort
- BiologyNeuroscience Letters
Functional Evaluations of Genes Disrupted in Patients with Tourette’s Disorder
- Biology, PsychologyFront. Psychiatry
Specific genes implicated in TD etiology are reviewed, the functions of these genes in the mammalian central nervous system are discussed, and functional analyses that can be performed are reviewed to evaluate the role(s) that the genetic disruptions might play in TD.
SHOWING 1-10 OF 237 REFERENCES
An individual with Gilles de la Tourette syndrome and Smith-Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes?
- Biology, PsychologyJournal of intellectual disability research : JIDR
The co-occurrence of GTS, SMS and their common behavioural/neuropsychiatric abnormalities should warrant further genetic investigation of chromosome 17p11.2 deletion site as it may be a promising region for containing a gene(s) of aetiological importance in the development of the GTS phenotype.
Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region.
- BiologyAmerican journal of human genetics
The findings warrant the further investigation of 17q25 as a candidate susceptibility region for GTS, and the background linkage disequilibrium (LD) of the region was studied in eight populations of European origin.
Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder population
- Biology, PsychologyMolecular Psychiatry
The notion that DRD4 and MOA-A genes may confer an increased risk for developing TS in the French Canadian population is supported.
Genetic and clinical analysis of a large Dutch Gilles de la Tourette family
- MedicineMolecular Psychiatry
The clinical evaluation of patients and family members in a large Dutch Gilles de la Tourette Syndrome pedigree and the decisions encountered with respect to phenotyping are described and an accurate definition of the Tourette phenotype is discussed.
Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette Syndrome
- BiologyAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Although there is no evidence of selection, the haplotype frequency variation seen around the world will need to be considered in any future association studies of this locus with GTS or any other neuropsychiatric disorder.
LACK OF ASSOCIATION BETWEEN SLITRK1var321 AND TOURETTE SYNDROME IN A LARGE FAMILY-BASED SAMPLE
A clinical sample of over 1,000 patients with TS and their family members was screened for SLITRK1 var321 to determine a more accurate estimate of the prevalence of this variant in the white TS clinic population and to test for any association between var321 and TS.
Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate.
- Biology, PsychologyPsychiatric genetics
These findings replicate the association of DRD2 and GTS, and are consistent with the proposed connection between the dopamine system and this complex neuropsychiatric disease.
Tourette disorder spectrum maps to chromosome 14q31.1 in an Italian kindred
There is strong evidence for linkage of TS spectrum to chromosome 14q31.1, and this region might contain an important gene for TS, and it should be prioritized for further study.
Gilles de la Tourette syndrome is not linked to D2-dopamine receptor.
- Biology, MedicineArchives of general psychiatry
A genetic linkage map of the region of DRD2 on the long arm of chromosome 11 and restriction fragment length polymorphism data from a total of four markers allowed us to exclude a Gilles de la Tourette syndrome susceptibility locus from a larger genetic region.
Genome scan for linkage to Gilles de la Tourette syndrome.
- PsychologyAmerican journal of medical genetics
This article test for linkage to TS in multigenerational families segregating TS using a panel of 386 markers with the largest interval between any two markers being 28 cM and an average distance between markers of 10 cM, and using nonparametric methods.