The genetic basis for specific anosmia to isovaleric acid in the mouse

@article{Griff1995TheGB,
  title={The genetic basis for specific anosmia to isovaleric acid in the mouse},
  author={Irene C. Griff and Randall R. Reed},
  journal={Cell},
  year={1995},
  volume={83},
  pages={407-414}
}
The detection and discrimination of odorants in mammals is thought to be mediated by a family of 100-1000 seven transmembrane domain receptor proteins, although none of these putative olfactory receptors have been shown to bind individual odorants with high affinity. We have used a genetic approach to identify the genomic regions responsible for the differential ability of two inbred mouse strains to detect a single odorant, isovaleric acid. Results obtained with a behavioral assay were… CONTINUE READING