The genetic basis and evolution of red blood cell sickling in deer

@inproceedings{Esin2017TheGB,
  title={The genetic basis and evolution of red blood cell sickling in deer},
  author={Alexander Esin and L. Therese Bergendahl and Vincent Savolainen and Joseph A. Marsh and Tobias Warnecke},
  booktitle={Nature Ecology & Evolution},
  year={2017}
}
Crescent-shaped red blood cells, the hallmark of sickle-cell disease, present a striking departure from the biconcave disc shape normally found in mammals. Characterized by increased mechanical fragility, sickled cells promote haemolytic anaemia and vaso-occlusions and contribute directly to disease in humans. Remarkably, a similar sickle-shaped morphology… CONTINUE READING