The genetic association between Cathepsin D and Alzheimer's disease.

@article{Crawford2000TheGA,
  title={The genetic association between Cathepsin D and Alzheimer's disease.},
  author={Fiona C. Crawford and Melissa J. Freeman and John A Schinka and Laila Abdullah and David Richards and Steven Sevush and Rajan Duara and Michael J. Mullan},
  journal={Neuroscience letters},
  year={2000},
  volume={289 1},
  pages={61-5}
}
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer's disease (AD) process because of its ability to cleave the beta-amyloid precursor protein and the possibility that it may be one of the 'secretase' enzymes. A functional C-->T polymorphism in the Cathepsin D gene (CATD) has been reported to be associated with increased risk for AD in Caucasian case-control studies; specifically, the T-carrying genotypes confer increased risk. We have examined this… CONTINUE READING

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The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
Aspartic Acid ProteasesIs biochemical function of gene productCATHEPSIN D
The aspartyl protease Cathepsin D has previously been suggested to play a role in the Alzheimer 's disease ( AD ) process because of its ability to cleave the beta - amyloid precursor protein and the possibility that it may be one of the ' secretase ' enzymes .
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