The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.

@article{Wang2004TheGA,
  title={The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.},
  author={Eric T. Wang and Y-C Ding and Pamela Flodman and Judith R. Kidd and Kenneth K. Kidd and Deborah L. Grady and Oliver A Ryder and M. Anne Spence and James M. Swanson and Robert K. Moyzis},
  journal={American journal of human genetics},
  year={2004},
  volume={74 5},
  pages={931-44}
}
Associations of the seven-repeat (7R) allele of the human dopamine receptor D4 (DRD4) gene with both the personality trait of novelty seeking and attention deficit/hyperactivity disorder have been reported. Recently, on the basis of the unusual DNA sequence organization of the DRD4 7R 48-bp tandem repeat (VNTR), we proposed that the 7R allele originated as a rare mutational event that increased to high frequency by positive selection. We now have resequenced the entire DRD4 locus from 103… CONTINUE READING
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