The genetic architecture of domestication in the chicken: effects of pleiotropy and linkage.

@article{Wright2010TheGA,
  title={The genetic architecture of domestication in the chicken: effects of pleiotropy and linkage.},
  author={Dominic Wright and C Rubin and Alvaro Martinez Barrio and Karin Sch{\"u}tz and Susanne Kerje and Helena Br{\"a}ndstr{\"o}m and Andreas Kindmark and Palle Waage Jensen and Leif Andersson},
  journal={Molecular ecology},
  year={2010},
  volume={19 23},
  pages={5140-56}
}
The extent of pleiotropy and epistasis in quantitative traits remains equivocal. In the case of pleiotropy, multiple quantitative trait loci are often taken to be pleiotropic if their confidence intervals overlap, without formal statistical tests being used to ascertain if these overlapping loci are statistically significantly pleiotropic. Additionally, the degree to which the genetic correlations between phenotypic traits are reflected in these pleiotropic quantitative trait loci is often… CONTINUE READING
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