The genetic and molecular pathogenesis of NF1 and NF2.

  title={The genetic and molecular pathogenesis of NF1 and NF2.},
  author={Kaleb H Yohay},
  journal={Seminars in pediatric neurology},
  volume={13 1},
Neurofibromatosis types 1 and 2 (NF1 and NF2) are autosomal dominant phakomatoses. The NF1 and NF2 genes encode for neurofibromin and merlin, respectively. These 2 functionally unrelated proteins both act as tumor suppressor genes, possibly through modulation of the RAS/RAC oncogenic pathways. Improved understanding of the mechanisms by which these tumor suppressors act may allow for medical therapies for neurofibromatosis and may offer insights for cancer therapeutics. 

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…