The genetic and environmental basis of atopic diseases

  title={The genetic and environmental basis of atopic diseases},
  author={Alexandros Grammatikos},
  journal={Annals of Medicine},
  pages={482 - 495}
The prevalence of atopic diseases has increased abruptly in recent years in most Westernized societies, making the question why this happened the topic of a heated debate. The best paradigm available to date to explain this steep rise, the ‘hygiene hypothesis’, supports that it is the excess ‘cleanliness’ of our environments that has led to the decline in the number of infectious stimuli that are necessary for the proper development of our immune system. Recent findings support that it is the… 

Factors Influencing Atopic Dermatitis Incidence in Offspring.

This review considers fundamental research into AD prevalence and factors that in the past were mistakenly thought to affect that prevalence, such as caesarean section and antigen avoidance.

Environmental factors and allergic diseases.

A review of contemporary knowledge on various environmental factors, that influence prevalence and course of allergic diseases, like asthma, allergic rhinitis, atopic dermatitis and also contact dermatitis is reviewed.

Role of the environment in the development of canine atopic dermatitis in Labrador and golden retrievers.

Canine and human atopic dermatitis are multifaceted diseases whose clinical development may be influenced by several factors, such as genetic background, environment, secondary infections, food and

Functional characterization of an allergy-associated regulatory variant at the human IL13 locus

The results showed that HS4 acts as a novel cis-acting element that up-regulates IL13 transcription in activated Th2 cells, and the enhancing activity of HS4 mapped within the 3′ end of this element and was dependent on binding/recruitment of the transcription factors NF90 and NF45.

Interactions between Measles, Mumps and Rubella(Mmr) Vaccines and Atopic Diseases in Children

It is hypothesize that judging the association between MMR vaccination and atopic diseases could not be fruitful in understanding different mechanisms and suggested the interactions between Gene-environment MMR vaccinations and atopy diseases that could clarify divergences between the results.

Investigation of the therapeutic potential of ES-62 in a murine model of SLE

ES-62 suppressed the production of IL-22 both prior to and following onset of disease suggesting a key role for this cytokine in lupus pathogenesis, a proposal confirmed by neutralization studies which demonstrated that IL- 22 played an essential role in the development of disease in the MRL/lpr mouse.

Die Rolle der Umwelt bei der Entstehung der caninen atopischen Dermatitis

Examination of environmental factors in 2 genetically close breeds of Labrador and Golden Retrievers supports the primary hypothesis that certain environmental factors may influence canine AD development.

Food intolerance testing and dietary manipulation in inflammatory bowel disease

The frequently observed compromise of the epithelial integrity of the gut in IBD and subsequent effect of the luminal content is addressed, which makes up the main part of the environmental stimulus, thus introducing the role of diet in I BD.

The anti-inflammatory properties of intravenous immunoglobulin in a murine model of allergic airway disease ; effects on the development of regulatory T-cells

Using a robust antigen-driven model of allergic airway disease, IVIg markedly attenuates airway inflammation and this effect is associated with the induction of Tregs from non-regulatory T cells in pulmonary tissues, and it is demonstrated that the antiinflammatory actions of IVIG are dependent on a population of pulmonary CD11c + dendritic cells (DCs).



A missing link in the hygiene hypothesis?

  • E. Gale
  • Medicine, Biology
  • 2002
The hygiene hypothesis proposes that this is due to reduced stimulation of the immune system by early intercurrent infection, and the proposed role would be one of immunomodulation rather than disease induction, possibly mediated by interaction with other influences upon the development of the mucosal immune system.

TIM-1, a novel allergy and asthma susceptibility gene

The discovery of a genetic interaction between HAV and TIM-1 provides the first molecular genetic evidence for the hygiene hypothesis.

Disconnection of man and the soil: reason for the asthma and atopy epidemic?

Reduced risk of atopic disorders in adults with Helicobacter pylori infection

There was a 30% reduction in the prevalence of all three atopic disorders in people who had active H. pylori infection, although for each individual atopic disorder the numbers were not quite large enough to reach statistical significance.

Role of microbial burden in aetiology of allergy and asthma

Early childhood infection and atopic disorder

Interpretation of the prediction of atopic disorders by immunisation with whole-cell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation.

The early life origins of asthma and related allergic disorders

  • J. Warner
  • Medicine
    Archives of Disease in Childhood
  • 2004
The best predictors of continuing asthma into adulthood are: early age of onset; sensitisation to house dust mites; reduced lung function; and the presence of bronchial hyperresponsiveness in childhood, irrespective of therapy.

The role of lymphocytes in allergic disease.

  • S. Romagnani
  • Biology
    The Journal of allergy and clinical immunology
  • 2000
The T(H)2 hypothesis offers exciting opportunities for the development of novel immunotherapeutic strategies targeted to address allergen-specific T(h)2 cells or T( H)2-derived effector molecules in atopic individuals.

Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing.

Differences in the neonatal gut microflora precede the development of atopy, suggesting a crucial role of the balance of indigenous intestinal bacteria for the maturation of human immunity to a nonatopic mode.