The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes.

@article{Matilainen2010TheGE,
  title={The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes.},
  author={Juha M Matilainen and Antti R{\"a}s{\"a}nen and Petra Gynther and Sami V{\"a}is{\"a}nen},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={121 1-2},
  pages={142-5}
}
A number of studies have described the effects of 1alpha,25(OH)2D3 in immune system. Most of the known effects of 1alpha,25(OH)2D3 are indirect since only two functional VDREs that regulate transcription of cytokine gene has been reported until today. In this study we have examined a possibility of direct transcriptional regulation of IL-2, IL-10 and IL-12B genes in activated Jurkat or THP-1 cells via liganded VDR by using gene expression analysis and chromatin immunoprecipitation assays… CONTINUE READING

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