The generation of phosphoserine stretches in phosphoproteins: mechanism and significance.

  title={The generation of phosphoserine stretches in phosphoproteins: mechanism and significance.},
  author={Luca Cesaro and Lorenzo A. Pinna},
  journal={Molecular bioSystems},
  volume={11 10},
In the infancy of studies on protein phosphorylation the occurrence of clusters of three or more consecutive phosphoseryl residues in secreted and in cellular phosphoproteins was reported. Later however, while the reversible phosphorylation of Ser, Thr and Tyr residues was recognized to be the most frequent and general mechanism of cell regulation and signal transduction, the phenomenon of multi-phosphorylation of adjacent residues was entirely neglected. Nowadays, in the post-genomic era, the… 

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