The generation of nerve impulses in mammalian axons by changing the concentrations of the normal constituents of extracellular fluid.

@article{Orchardson1978TheGO,
  title={The generation of nerve impulses in mammalian axons by changing the concentrations of the normal constituents of extracellular fluid.},
  author={Robin Orchardson},
  journal={The Journal of physiology},
  year={1978},
  volume={275},
  pages={177-89}
}
1. Experiments have been performed to determine what changes in normal constituents of extracellular fluid are necessary to generate action potentials in mammalian axons. 2. Single and multifibre preparations of rat spinal roots were tested with Krebs solutions in which Na+, K+, Ca2+, Mg2+, pH, PCO2 or osmotic pressure were varied. 3. [Ca2+] below 1.0 mM produced impulses in all preparations. Lowering [Mg2+] did not generate any impulses but did enhance the response to low [Ca2+]. 4. Increasing… CONTINUE READING

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