The generation of monoclonal antibodies in mice: influence of adjuvants on the immune response, fusion efficiency and distress.

@article{Ferber1999TheGO,
  title={The generation of monoclonal antibodies in mice: influence of adjuvants on the immune response, fusion efficiency and distress.},
  author={Philippe C. Ferber and Pete Ossent and Felix R. Homberger and Ren{\'e} W. Fischer},
  journal={Laboratory animals},
  year={1999},
  volume={33 4},
  pages={334-50}
}
The objective of this study was to find a reliable alternative to Freund's adjuvant in order to reduce the distress imposed on the animals without impairing the fusion efficiency for immune-positive clones. For this purpose several commercially available adjuvants and adjuvant formulations representing different classes of molecules were compared. Humoral responses and animals' distress evaluated by clinical assessment and histopathological examinations were investigated and compared to fusion… CONTINUE READING

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