The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.

@article{Kunkl1981TheGO,
  title={The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.},
  author={Annalisa Kunkl and Gerry G. B. Klaus},
  journal={Immunology},
  year={1981},
  volume={43 2},
  pages={
          371-8
        }
}
Hapten (DNP)-specific B-memory cells were induced by priming mice with soluble or alum precipitated DNP-haemocyanin (KLH) plus Bordetella pertussis or CNP-KLH-anti-DNP antibody complexes at equivalence. Cells from mice given complexes gave a substantial adoptive IgG response five days after priming, whereas those from mice given antigen with conventional adjuvant did not give a comparable response until day 14. Soluble antigen induced poor memory, even 14 days after primary immunization. The… CONTINUE READING

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