The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens

@article{Wilson1977TheGO,
  title={The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens},
  author={Darcy B. Wilson and Kirstein Fischer Lindahl and Dianne H. Wilson and Jonathan Sprent},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={146},
  pages={361 - 367}
}
Negatively selected mouse and rat lymphocyte populations, specifically deprived of alloreactivity to a particular major histocompatibility complex (MHC) haplotype, are nevertheless fully capable of responding to trinitrophenyl (TNP)-modified allogeneic stimulator cells and developing cytotoxic T-lymphocyte activity to TNP-altered allogeneic target cells. As for syngeneic systems, lytic expression of those responder killer cells also requires MHC identity between the target and stimulator cell… CONTINUE READING

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