The generation of antibody-secreting plasma cells

@article{Nutt2015TheGO,
  title={The generation of antibody-secreting plasma cells},
  author={Stephen L. Nutt and Philip D. Hodgkin and David Mathew Tarlinton and Lynn M. Corcoran},
  journal={Nature Reviews Immunology},
  year={2015},
  volume={15},
  pages={160-171}
}
The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this… Expand
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