The generation of antibody-secreting plasma cells

  title={The generation of antibody-secreting plasma cells},
  author={Stephen L. Nutt and Philip D. Hodgkin and David Mathew Tarlinton and Lynn M. Corcoran},
  journal={Nature Reviews Immunology},
The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this… 

Regulation of Plasma Cell Differentiation.

Recent progress in the understanding of the cellular and molecular basis for plasma cell differentiation from GC B cells is reviewed.

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This work has shown that the differentiation of GC B cells toward a plasma cell fate is associated with affinity for antigens and is determined by the strength of contact with T follicular helper cells.

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Single-Cell Technologies for the Study of Antibody-Secreting Cells

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Regulatory plasma cells.

  • S. Fillatreau
  • Biology, Medicine
    Current opinion in pharmacology
  • 2015

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