The generation of antibody-secreting plasma cells

@article{Nutt2015TheGO,
  title={The generation of antibody-secreting plasma cells},
  author={Stephen L. Nutt and Philip D. Hodgkin and David Mathew Tarlinton and Lynn M. Corcoran},
  journal={Nature Reviews Immunology},
  year={2015},
  volume={15},
  pages={160-171}
}
The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this… 

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References

SHOWING 1-10 OF 166 REFERENCES

Competence and competition: the challenge of becoming a long-lived plasma cell

TLDR
Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past.

Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate lymphocyte differentiation

TLDR
It is reported here that the generation of immunoglobulin G–secreting cells from naive precursors is highly predictable and has the potential to simplify the concept of immune complexity considerably.

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

TLDR
While humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.

Germinal center selection and the development of memory B and plasma cells

TLDR
A model encompassing recent data from several laboratories is presented that suggests that the GC undergoes a temporal switch that alters the nature of its output from MBCs to PCs as the response progresses, and this will be discussed in the broader context of the origins of both cell types.

High affinity germinal center B cells are actively selected into the plasma cell compartment

TLDR
This work describes a powerful new model that allows these processes to be followed as they occur in vivo, and shows how “quality control” over plasma cell differentiation is likely critical for establishing effective humoral immunity.

Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

TLDR
Immunoglobulin variable region gene sequencing, and 5-bromo-2′-deoxyuridine pulse–chase studies indicate that long-lived splenic plasma cells are a mixture of cells derived from the extrafollicular and germinal center responses and cellsderived from virgin and memory B cells.

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

TLDR
It is found that the inhibitory Fc receptor FcγRIIb was expressed on plasma cells and controlled their persistence in the bone marrow, and defects in it may contribute to autoantibody production.
...