The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.

@article{Bollard2004TheGA,
  title={The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.},
  author={Catherine M Bollard and Karin C M Straathof and Mary Helen Huls and Alan Leen and Kristine Lacuesta and Alan R. Davis and Stephen Gottschalk and Malcolm K. Brenner and Helen E Heslop and Cliona M Rooney},
  journal={Journal of immunotherapy},
  year={2004},
  volume={27 4},
  pages={
          317-27
        }
}
Cellular adoptive immunotherapy for virus-associated malignant disease is an attractive strategy, since viral antigens provide targets for specific T lymphocytes. In Epstein-Barr virus (EBV)-positive Hodgkin disease (HD), a limited number of EBV-encoded antigens such as the latent membrane antigens (LMP) 1 and 2 are expressed on the malignant Reed-Sternberg cells. The authors aimed to generate cytotoxic T lymphocytes (CTLs) from patients with relapsed HD by specifically targeting LMP2A… CONTINUE READING

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