The generalized anxiety spectrum: prevalence, onset, course and outcome

  title={The generalized anxiety spectrum: prevalence, onset, course and outcome},
  author={Jules Angst and Alex Gamma and David S. Baldwin and Vladeta Ajdacic-Gross and Wulf R{\"o}ssler},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  • J. Angst, A. Gamma, W. Rössler
  • Published 1 February 2009
  • Psychology, Medicine
  • European Archives of Psychiatry and Clinical Neuroscience
BackgroundGeneralized anxiety disorder (GAD) is generally considered to be a chronic condition, waxing and waning in severity; however prospective investigation of the course of GAD in community samples is lacking. This study seeks to fill that gap, by identifying the whole spectrum of generalized anxiety syndromes, sub-typing them according to their duration and frequency of occurrence, and evaluating their long-term course and outcome in the community.MethodThe prospective Zurich Study… 

On the Diagnosis, Assessment, and Treatment of Generalized Anxiety Disorder

Generalized anxiety disorder (GAD) is increasingly recognized as a prevalent anxiety disorder with a chronic course and signifi cant impairment (APA, 2000; Ballenger et al., 2001; Weisberg, 2009).

Prevalence and clinical characteristics of remission during treatment in generalized anxiety

Findings underline the poor prognosis of generalized anxiety and highlight the need to further investigate factors affecting this prevalence.

The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review

Subthreshold GAD is a common, recurrent and impairing disease with verifiable morbidity that claims significant healthcare resources and should receive additional research and clinical attention.

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The GAD-7 Scale appears to be a valid measure of generalized anxiety symptoms in this sample, on the basis of good internal consistency, convergent validity and sensitivity to change, but does not perform well as a screener for GAD.

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The results of the study showed that an encompassing GAD (including performance and social anxiety) has an early onset, recognized partially in childhood, but mostly during adolescence.

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To evaluate the potential impact of early childhood problems on the chronicity of mood disorders. A representative cohort from the population was prospectively studied from ages 19/20 to 39/40.

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  • J. NilssonS. Östling I. Skoog
  • Psychology, Medicine
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There was greater congruence between GAD in either classification system and depression than between DSM-IV/V GAD and ICD-10 GAD, emphasizing the close link between these entities.

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SP and OCD comorbidities were found to be prevalent and disabling among GAD and PD patients, with higher subthreshold than threshold rates, and a negative impact on quality of life.

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Physicians working at primary health care centers in Jeddah showed significant rate of generalized anxiety disorders particularly younger and Saudi physicians.

Generalized anxiety disorder.




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In this epidemiological sample, the 6-month duration criterion for GAD could not be confirmed as clinically meaningful and GAD syndromes of varying duration form a continuum with comparable clinical relevance.

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Community epidemiological data are used to study the implications of changing the DSM-IV requirement that episodes of generalized anxiety disorder must persist for at least 6 months for estimates of prevalence, onset, course, impairment, co-morbidity, associations with parental GAD, and sociodemographic correlates.

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We compared demographic and comorbidity profiles of subjects with varying levels of anxiety pathology to test if the clinical characteristics of generalized anxiety disorder (GAD) subjects differed

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  • H. Wittchen
  • Psychology, Medicine
    Depression and anxiety
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Generalized anxiety disorder is a prevalent and disabling disorder characterized by persistent worrying, anxiety symptoms, and tension and is associated with a significant economic burden owing to decreased work productivity and increased use of health care services, particularly primary health care.

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The findings reveal that psychiatric disorders are quite common in the general population, and when the spectra of mental disorders are considered, nearly three quarters of the generalpopulation will have manifested at least one of the mental disorders across their lifetime.

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The findings largely support the hypothesis of a continuum from mild and short to more severe, longer lasting depressive syndromes, but they do not exclude heterogeneity of RBD.

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Since its inception as a diagnostic category in 1980, the definitional criteria for generalized anxiety disorder (GAD) have been revised substantially in each edition of the Diagnostic and

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The literature shows clearly that GAD is a commonly occurring disorder associated with serious impairment and Coordinated community epidemiologic studies and treatment effectiveness studies are needed to resolve remaining uncertainties regarding the diagnostic boundaries of GAD.

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Primary analyses found unipolar disorders to be four times more common in GAD than bipolar disorders (67% vs. 17%), providing indirect support for the previously reported observation that GAD and major depression may share a common genetic diathesis.