The gene for type A streptococcal exotoxin (erythrogenic toxin) is located in bacteriophage T12

@article{Weeks1984TheGF,
  title={The gene for type A streptococcal exotoxin (erythrogenic toxin) is located in bacteriophage T12},
  author={C R Weeks and Joseph J. Ferretti},
  journal={Infection and Immunity},
  year={1984},
  volume={46},
  pages={531 - 536}
}
The infection of Streptococcus pyogenes T25(3) with the temperate bacteriophage T12 results in the conversion of the nontoxigenic strain to type A streptococcal exotoxin (erythrogenic toxin) production. Although previous research has established that integration of the bacteriophage genome into the host chromosome is not essential for exotoxin production, the location of the gene on the bacteriophage or bacterial chromosome had not been determined. In the present investigation, recombinant DNA… Expand
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The results suggest that there is a strain specificity to the phage-host interaction which affects type A exotoxin synthesis and indicates that type A streptococcal exot toxin was not a structural component of phage T12. Expand
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