The gene for familial polyposis coli maps to the long arm of chromosome 5.

@article{Leppert1987TheGF,
  title={The gene for familial polyposis coli maps to the long arm of chromosome 5.},
  author={Mark F. Leppert and Marion Dobbs and Peter J. Scambler and P. O'Connell and Yusuke Nakamura and D. Stauffer and Scott Woodward and Rachel Burt and James P. Hughes and Emily Gardner},
  journal={Science},
  year={1987},
  volume={238 4832},
  pages={1411-3}
}
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

Recent Discoveries in the Genetics of Familial Colorectal Cancer and Polyposis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2017

Similar Papers

Loading similar papers…