The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts

  title={The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts},
  author={Shaoqiong Chen and Sarah C McLean and David E. Carter and Andrew Leask},
  journal={Journal of Cell Communication and Signaling},
Wnt proteins play important roles in regulating cell differentiation, proliferation and polarity. Wnts have been proposed to play roles in tissue repair and fibrosis, yet the gene expression profile of fibroblasts exposed to Wnts has not been examined. We use Affymetrix genome-wide expression profiling to show that a 6-h treatment of fibroblasts of Wnt3a results in the induction of mRNAs encoding known Wnt targets such as the fibrogenic pro-adhesive molecule connective tissue growth factor… CONTINUE READING


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