The gene encoding mycobacterial DNA-binding protein I (MDPI) transformed rapidly growing bacteria to slowly growing bacteria.

@article{Matsumoto2000TheGE,
  title={The gene encoding mycobacterial DNA-binding protein I (MDPI) transformed rapidly growing bacteria to slowly growing bacteria.},
  author={Shinichi Matsumoto and Makoto Furugen and Hideharu Yukitake and Takeshi Yamada},
  journal={FEMS microbiology letters},
  year={2000},
  volume={182 2},
  pages={297-301}
}
Pathogenic species of Mycobacterium are slowly growing intracellular bacteria. Slow growth is important for the parasitism of these organisms and chronicity of the disease, but its precise mechanism has not been elucidated. Recently, we found that a novel DNA-binding protein (MDPI) was expressed (7-10% in total protein) in mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin, Mycobacterium tuberculosis, and Mycobacterium leprae. In this study, we observed that MDPI interfered with… CONTINUE READING
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