The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12–p13 and description of a DNA polymorphism

@article{Alitalo2004TheGE,
  title={The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12–p13 and description of a DNA polymorphism},
  author={Tiina Alitalo and Kimmo K. Kontula and Riitta Koistinen and Katriina Aalto-Set{\"a}l{\"a} and Mervi Julkunen and Olli A. J{\"a}nne and Markku Seppälä and Albert de la Chapelle},
  journal={Human Genetics},
  year={2004},
  volume={83},
  pages={335-338}
}
SummaryThe low-molecular weight insulin-like growth-factor binding protein (IGF-BP25) is synthesized by human liver, secretory endometrium and decidua, and is also present in human serum. It binds insulin-like growth factors IGF-I and IGF-II with high affinity, and is proposed to act as a paracrine regulator of cell growth. In situ hybridization studies with a cDNA encompassing the entire protein coding region of IGF-BP25 localized the gene to bands p12–p13 on chromosome 7. Southern blot… 
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The chromosomal localization was determined for the gene encoding IGFBP4, i.e. inhibitory-IGFBP, to chromosomal region 17q21–21 in agreement with PCR analysis of a panel of somatic cell hybrids.
Assignment of the Gene for Porcine Insulin-Like Growth Factor Binding Protein 1 to Chromosome 18 and Detection of Polymorphisms in Intron 2 by PCR–RFLP
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Results of fluorescence in situ and radiation hybrid mapping assigned this gene to porcine chromosome 18q24-qter and two types of polymerase chain reaction–restriction-fragment-length polymorphisms (PCR–RFLP) in intron 2 were found.
The insulin-like growth factor family of ligands, receptors, and binding proteins
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There is great potential for complex interactions between the family members that could ultimately regulate normal and neoplastic cell growth.
INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS-1 AND -3 AND SEX HORMONE-BINDING GLOBULIN: STUDIES ON REGULATION OF SYNTHESIS IN VITRO, AND CLINICAL ASPECTS
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The present study focused on the regulation of IGFBP-1 and SHBG in metABOLIC SYNDROME and DIABETES, as well as the IGF system in deliveries andfetalmembranes, and its role in PREGNANCY.
Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - consensus and dissent on metabolic control and malignant potential.
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