The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12–p13 and description of a DNA polymorphism

@article{Alitalo2004TheGE,
  title={The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12–p13 and description of a DNA polymorphism},
  author={Tiina Alitalo and Kimmo K. Kontula and Riitta Koistinen and Katriina Aalto-Set{\"a}l{\"a} and Mervi Julkunen and Olli A. J{\"a}nne and Markku Seppälä and Albert de la Chapelle},
  journal={Human Genetics},
  year={2004},
  volume={83},
  pages={335-338}
}
SummaryThe low-molecular weight insulin-like growth-factor binding protein (IGF-BP25) is synthesized by human liver, secretory endometrium and decidua, and is also present in human serum. It binds insulin-like growth factors IGF-I and IGF-II with high affinity, and is proposed to act as a paracrine regulator of cell growth. In situ hybridization studies with a cDNA encompassing the entire protein coding region of IGF-BP25 localized the gene to bands p12–p13 on chromosome 7. Southern blot… 
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References

SHOWING 1-10 OF 28 REFERENCES
Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.
TLDR
Comparison of full-length protein sequences for the IGF-I and IGF-II receptors with that of the HEP G2 IGF binding protein fails to demonstrate any significant similarities among these three proteins, and suggests that each contains a unique binding domain forThe IGF peptides.
Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.
By N-terminal sequence comparison it was shown that the placental protein 12 (PP12) is homologous to the IGF I (insulin-like growth factor) and somatomedin binding protein. Starting with an antibody
Insulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells.
TLDR
It is concluded that JEG-3 cells represent a cell type that can produce IGF, but not IGF-BPs and may provide a useful model system for a better understanding of autocrine growth regulation mediated by the IGFs.
Cloning, characterization, and expression of a human insulin-like growth factor binding protein.
An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
TLDR
It is concluded that a form of IGF binding protein that is present in extracellular fluids and is secreted by many types of cells can markedly potentiate the cellular response to IGF-I.
The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells.
Partial purification and characterization of a binding protein for insulin-like activity (ILAs) in human amniotic fluid: a possible inhibitor of insulin-like activity.
TLDR
Amniotic fluid binding protein or AFBP inhibits the activity of employed insulin, in the INS-RRA, presumably by binding ILAs, while being inactive itself, raising the possibility that binding protein(s) for insulin-like peptides may function as inhibitors of their bioactivity in different physiologic and pathologic states.
Different insulin-like growth factor binding species in human placenta and decidua.
TLDR
The results suggest that the decidual 34K IGF-BP might act as a local modulator of the IGF action at the interface between thedecidua and the placenta.
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