The gene encoding human glutathione synthetase (GSS) maps to the long arm of chromosome 20 at band 11.2.

@article{Webb1995TheGE,
  title={The gene encoding human glutathione synthetase (GSS) maps to the long arm of chromosome 20 at band 11.2.},
  author={Graham C. Webb and V L Vaska and Rayappa Reddy Gali and Judith Helen Ford and Philip G Board},
  journal={Genomics},
  year={1995},
  volume={30 3},
  pages={617-9}
}
Two forms of glutathione synthetase deficiency have been described. While one form is mild, causing hemolytic anemia, the other more severe form causes 5-oxo-prolinuria with secondary neurological involvement. Despite the existence of two deficiency phenotypes, Southern blots hybridized with a glutathione synthetase cDNA suggest that there is a single glutathione synthetase gene in the human genome. Analysis of somatic cell hybrids showed the human glutathione synthetase gene (GSS) to be… CONTINUE READING

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