The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone.

@article{Montonen1998TheGD,
  title={The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone.},
  author={Outi Montonen and Sini Ezer and Ulpu K Saarialho-Kere and Riitta Herva and M-L Karjalainen-Lindsberg and Ilkka I Kaitila and David Schlessinger and Apurva K. Srivastava and Irma Thesleff and Juha Kere},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1998},
  volume={46 3},
  pages={281-9}
}
Anhidrotic ectodermal dysplasia (EDA) is characterized by defects in the development of teeth, hair, and sweat glands. To study the expression of the human gene defective in EDA in human fetal development (Weeks 6-23 of gestational age) and in adult tissues, in situ hybridization and immunohistochemistry were used. First signs of expression were detected at Week 8 in epidermis and in neuroectodermal cells. Starting at Week 12, osteoblasts and thymus were positive for EDA mRNA. Hair follicles… CONTINUE READING

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