The gene 4 protein of bacteriophage T7. Characterization of helicase activity.

@article{Matson1983TheG4,
  title={The gene 4 protein of bacteriophage T7. Characterization of helicase activity.},
  author={Steven W. Matson and Stanley Tabor and Charles C. Richardson},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 22},
  pages={14017-24}
}
Gene 4 protein of bacteriophage T7 is a multifunctional enzyme that both stimulates T7 DNA polymerase during leading strand synthesis, and synthesizes RNA primers that initiate lagging strand synthesis. Both activities are dependent on the ability of the gene 4 protein to translocate unidirectionally (5' to 3') along single-stranded DNA (Tabor, S., and Richardson, C.C. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 205-209), a reaction that is coupled to the hydrolysis of nucleoside 5… CONTINUE READING

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