The gaussian network model: precise prediction of residue fluctuations and application to binding problems.

Abstract

The single-parameter Gamma matrix of force constants proposed by the Gaussian Network Model (GNM) is iteratively modified to yield native state fluctuations that agree exactly with experimentally observed values. The resulting optimized Gamma matrix contains residue-specific force constants that may be used for an accurate analysis of ligand binding to… (More)

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Cite this paper

@article{Erman2006TheGN, title={The gaussian network model: precise prediction of residue fluctuations and application to binding problems.}, author={Burak Erman}, journal={Biophysical journal}, year={2006}, volume={91 10}, pages={3589-99} }