The gate controlling cell wall synthesis in Staphylococcus aureus.

  title={The gate controlling cell wall synthesis in Staphylococcus aureus.},
  author={Hitoshi Komatsuzawa and Tamaki Fujiwara and Hiromi Nishi and Sakuo Yamada and Masaru Ohara and Nadine G. McCallum and Brigitte Berger-B{\"a}chi and Motoyuki Sugai},
  journal={Molecular microbiology},
  volume={53 4},
Glucosamine-6-P occupies a central position between cell wall synthesis and glycolysis. In the initial steps leading to peptidoglycan precursor formation glucosamine-6-P is processed sequentially to UDP-N-acetylglucosamine, while to enter the glycolysis pathway, glucosamine-6-P is isomerized by NagB to fructose-6-P. Although we could not demonstrate NagB activity, nagB inactivation significantly reduced growth. Mutational analysis showed that NagA was involved in glucosamine-6-P formation from… CONTINUE READING

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