The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection.

@article{Mehandru2005TheGT,
  title={The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection.},
  author={Saurabh Mehandru and Klara Tenner-Racz and Paul Racz and Martin Markowitz},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 2},
  pages={419-22}
}
It has become evident that the gastrointestinal tract is preferentially and profoundly depleted of CD4+ T cells during acute HIV-1 infection. The enhanced susceptibility of gastrointestinal lymphoid tissue to HIV-1 is in part due to the large complement of CCR5+ memory CD4+ T cells resident at this site. Here we summarize the recent findings demonstrating that the gastrointestinal tract plays a critical role in the pathogenesis of acute HIV-1 and simian immunodeficiency virus infections… CONTINUE READING

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