The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling.

@article{Agnew2012TheGP,
  title={The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling.},
  author={Andrew J Agnew and Emma Robinson and Carmel Mary McVicar and Adam P. Harvey and Imran H. A. Ali and Jennifer E. Lindsay and Denise McDonald and Brian Desmond Green and David J Grieve},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 1},
  pages={327-38}
}
BACKGROUND AND PURPOSE Obestatin is a recently discovered gastrointestinal peptide with established metabolic actions, which is linked to diabetes and may exert cardiovascular benefits. Here we aimed to investigate the specific effects of obestatin on vascular relaxation. EXPERIMENTAL APPROACH Cumulative relaxation responses to obestatin peptides were… CONTINUE READING