The gastrointestinal microflora of irradiated mice. II. Effect of oral antibiotic administration on the colonic flora and survival of adult mice.

Abstract

Postirradiation survival has been related to the suppression of intestinal coliform bacteria.' Germ-free animals routinely exhibit less diarrhea, melena, and weight loss and survive radiation doses that are lethal for conventional animals.2` Oral antibiotics, especially those which reach high concentration in the lumen of the gut, prevent bacteremia and in some instances have been reported to prolong life or prevent death."' Presumably this is accomplished by limiting proliferation of susceptible intestinal organisms. In this paper, we report the effect of oral antibiotics on colonic bacteria in lethally irradiated adult mice with special reference to mean survival time and survival rates.

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Cite this paper

@article{Livstone1970TheGM, title={The gastrointestinal microflora of irradiated mice. II. Effect of oral antibiotic administration on the colonic flora and survival of adult mice.}, author={Elliot M. Livstone and Theodore Hersh and H. Spiro and Martin H. Floch}, journal={The Yale Journal of Biology and Medicine}, year={1970}, volume={42}, pages={448 - 454} }