The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.

  title={The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.},
  author={S. P. Singh and Anamika Khajuria and Subhash Chandra Taneja and Ravi Kant Khajuria and J. P. Singh and Rakesh Kamal Johri and Ghulam Nabi Qazi},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={15 6-7},
  • S. Singh, A. Khajuria, G. N. Qazi
  • Published 20 June 2008
  • Medicine, Chemistry
  • Phytomedicine : international journal of phytotherapy and phytopharmacology

Methanol Extract of Bauhinia purpurea Leaf Possesses Anti-Ulcer Activity

MEBP exhibited anti-ulcer activity, which could be due to the presence of flavonoids, saponins or other polyphenols, thereby validating the traditional use of B. purpurea in the treatment of ulcers.

Study on phytochemical profile and anti-ulcerogenic effect of Cayratia pedatata Lam in albino wistar rats

Cayratia pedata leaves extract have potential anti-ulcer activity in this tested models and show significant reduction in ulcer index in ethanol induced model with respect to control.

Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn).

  • E. ShakerH. MahmoudS. Mnaa
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010

Evaluation of anti-ulcer activity of Pluchea indica (L) Less in various ulcer models in rats

The extract in dose of 40 and 160 mg/kg body weight had a significant anti-ulcerogenic activity against gastric ulcer induced by NaOH and indomethacin and at lower dose, the extract also significantly increased the gastric wall mucous content in pyloric ligated rats.

The Gastroprotective Role of Acanthus ilicifolius – A Study to Unravel the Underlying Mechanism of Anti-Ulcer Activity

Results suggest that extracts of the leaves of Acanthus ilicifolius may exhibit anti-ulcer activities additional to the anti-inflammatory properties.

Comparative evaluation of the efficacy of Cardiospermum halicacabum Linn. on Indomethacin, Pylorus ligation and Helicobacter pylori induced gastric ulcer in rats

The alcohol extract of C. halicacabum showed better antiulcer activity against ulcers induced by indomethacin and pylorus ligation dose dependently, however, the same extract failed to show any anti H. pylori activity when monitored both in vitro and in vivo.


It is suggested that Ethanol Extract of the leaves of Trewia nudiflora possess anti-ulcerogenic properties that may be due to cytoprotective mechanism.

Exploiting the phenomenal anti-ulcerogenic potential of Talinum portulacifolium ethanolic extract whole plant on Albino Rats: The therapeutic potential of Chinese Herb-mǎ chǐ xiàn kē (Portulacaceae)

The ethanolic extract of T. portulacifolium plant was found to possess a significant antiulcer activity and significantly protected the ulceration induced by the three models.

Boswellia serrata

This review underlines BSE as a promising alternative to NSAIDs, which warrants investigation in further pharmacological studies and clinical trials and presents different perspectives and gives a differentiated insight into the possible mechanisms of action of BSE in humans.



Anti-inflammatory actions of boswellic acids.

Gastric ulcerogenicity of non‐steroidal anti‐inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment

  • K. Rainsford
  • Medicine, Biology
    The Journal of pharmacy and pharmacology
  • 1987
A novel technique is described for the assay of acute gastric irritancy of non‐steroidal anti‐inflammatory drugs (NSAIDs) in mice in which (a) the gastric mucosa is sensitized to the irritant actions

Pathogenesis of peptic ulcer disease and current trends in therapy.

Current knowledge about the pathogenesis of peptic ulcer disease is described, the influence of environmental factors and speculation on the role of a recently characterized bacterial organism, Helicobacter pylori are described.

Immunomodulatory Activity of Boswellic Acids (Pentacyclic Triterpene Acids) from Boswellia serrata

Prolonged oral administration of Boswellic acids increased the body weight, total leukocyte counts and humoral antibody titres in rats, and is not cytotoxic nor does it cause immunosuppression.

Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.

The results of this study suggest the effectiveness of Boswellia serrata extract with defined content of boswellic acids in inducing dose-dependent antiproliferative effects on all human malignant cells tested.

Anti-ulcer drugs of plant origin.

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the5-LO or blocking its translocation.

Effect of polyamines on acidified ethanol-induced gastric lesions in rats.

The results suggest that the cytoprotective effect of spermine may not be mediated by endogenous prostaglandins or alkaline secretion in the gastric mucosa, but may be partially related to endogenous sulfhydryl compounds.

Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine.

The results indicate that KB-5492 has potent and broad anti-ulcer properties, which are probably exerted by its enhancement of gastric mucosal defensive factors through increasing gastrics mucosal blood flow and/or retaining gastRIC mucus, and not by its inhibition of Gastric acid secretion.