The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.

@article{Singh2008TheGU,
  title={The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.},
  author={S. P. Singh and Anamika Khajuria and Subhash Chandra Taneja and Ravi Kant Khajuria and J. P. Singh and Rakesh Kamal Johri and Ghulam Nabi Qazi},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2008},
  volume={15 6-7},
  pages={
          408-15
        }
}
  • S. Singh, A. Khajuria, G. N. Qazi
  • Published 20 June 2008
  • Medicine, Chemistry
  • Phytomedicine : international journal of phytotherapy and phytopharmacology

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Boswellia serrata

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...

References

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Anti-inflammatory actions of boswellic acids.

Gastric ulcerogenicity of non‐steroidal anti‐inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment

  • K. Rainsford
  • Medicine, Biology
    The Journal of pharmacy and pharmacology
  • 1987
A novel technique is described for the assay of acute gastric irritancy of non‐steroidal anti‐inflammatory drugs (NSAIDs) in mice in which (a) the gastric mucosa is sensitized to the irritant actions

Pathogenesis of peptic ulcer disease and current trends in therapy.

TLDR
Current knowledge about the pathogenesis of peptic ulcer disease is described, the influence of environmental factors and speculation on the role of a recently characterized bacterial organism, Helicobacter pylori are described.

Immunomodulatory Activity of Boswellic Acids (Pentacyclic Triterpene Acids) from Boswellia serrata

TLDR
Prolonged oral administration of Boswellic acids increased the body weight, total leukocyte counts and humoral antibody titres in rats, and is not cytotoxic nor does it cause immunosuppression.

Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.

TLDR
The results of this study suggest the effectiveness of Boswellia serrata extract with defined content of boswellic acids in inducing dose-dependent antiproliferative effects on all human malignant cells tested.

Anti-ulcer drugs of plant origin.

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

TLDR
The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the5-LO or blocking its translocation.

Effect of polyamines on acidified ethanol-induced gastric lesions in rats.

TLDR
The results suggest that the cytoprotective effect of spermine may not be mediated by endogenous prostaglandins or alkaline secretion in the gastric mucosa, but may be partially related to endogenous sulfhydryl compounds.

Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine.

TLDR
The results indicate that KB-5492 has potent and broad anti-ulcer properties, which are probably exerted by its enhancement of gastric mucosal defensive factors through increasing gastrics mucosal blood flow and/or retaining gastRIC mucus, and not by its inhibition of Gastric acid secretion.