The gastric secretion of drugs: a pH partition hypothesis.

@article{Shore1957TheGS,
  title={The gastric secretion of drugs: a pH partition hypothesis.},
  author={Parkhurst Allan Shore and Bernard B. Brodie and C. Adrian M. Hogben},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1957},
  volume={119 3},
  pages={
          361-9
        }
}
Parenterally administered drugs are secreted directly into the gastric juice. The concentration ratio (concentration of drug in gastric juice divided by concentration in plasma) depends on the dissociation constant of the drug. Thus strong acids appear in gastric juice in negligible concentration, weak acids and weak bases in measurable amount and stronger bases in highest concentration. The stronger bases appear in a limiting concentration ratio of about 40 to 1 when gastric juice flow is… CONTINUE READING

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