The gastric H,K ATPase as a drug target: past, present, and future.

  title={The gastric H,K ATPase as a drug target: past, present, and future.},
  author={George Sachs and Jai Moo Shin and Olga Vagin and Nils Lambrecht and Iskandar Yakubov and Keith Munson},
  journal={Journal of clinical gastroenterology},
  volume={41 Suppl 2},
The recent progress in therapy if acid disease has relied heavily on the performance of drugs targeted against the H,K ATPase of the stomach and the H2 receptor antagonists. It has become apparent in the last decade that the proton pump is the target that has the likelihood of being the most sustainable area of therapeutic application in the regulation of acid suppression. The process of activation of acid secretion requires a change in location of the ATPase from cytoplasmic tubules into the… CONTINUE READING
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