The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts.

@article{Li2002TheGJ,
  title={The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts.},
  author={Guohu Li and Peter Whittaker and Mu Yao and Robert A. Kloner and Karin Przyklenk},
  journal={Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology},
  year={2002},
  volume={11 3},
  pages={158-65}
}
BACKGROUND Emerging evidence suggests that gap junction-mediated intercellular transmission of ions, metabolites and/or second messengers may serve as important determinants of myocyte viability. Our aim was to determine, using isolated buffer-perfused mouse hearts, whether the cardioprotection achieved with ischemic preconditioning (PC) is due in part to: (i) disruption of cell-cell coupling (manifest as a loss in the primary gap junction protein, connexin 43 [Cx43]) and resultant impaired… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…