The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway.

@article{Laing1995TheGJ,
  title={The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway.},
  author={James G Laing and Eric C Beyer},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 44},
  pages={26399-403}
}
We investigated the degradation of the gap junction protein connexin43 in E36 Chinese hamster ovary cells and rat cardiomyocyte-derived BWEM cells. Treatment of E36 cells with the lysosomotropic amine, primaquine, for 16 h doubled the amount of connexin43 detected by immunoblotting and modestly increased the half-life of connexin43 in pulse-chase studies, suggesting that the lysosome played a minor role in connexin43 proteolysis. In contrast, treatment with the proteasomal inhibitor N-acetyl-L… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
87 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…