The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

@article{Selliah2006TheGR,
  title={The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.},
  author={Nithianandan Selliah and Mingce Zhang and Dennis C DeSimone and Hellen Kim and Michael Brunner and Richard Ittenbach and Hallgeir Rui and Randy Quentin Cron and Terri Helman Finkel},
  journal={Virology},
  year={2006},
  volume={344 2},
  pages={283-91}
}
Although HIV-1 (HIV) replicates poorly in non-dividing CD4 lymphocytes, resting T cells contribute to the latent reservoir. The gammac-related cytokines reverse this block to HIV infection; however, the molecular mechanisms controlling this process are not understood. We asked whether the gammac-cytokine regulated transcription factor, signal transducer and activator of transcription 5 (STAT5), activates HIV transcription. We identified three regions in the long terminal repeat (LTR) as close… CONTINUE READING
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