The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site.

@article{Granovsky1997TheGS,
  title={The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site.},
  author={Alexey E. Granovsky and Michael Natochin and Nikolai O Artemyev},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 18},
  pages={
          11686-9
        }
}
Cyclic GMP phosphodiesterase (PDE) is the effector enzyme in the visual transduction cascade of vertebrate photoreceptor cells. In the dark, the activity of the enzyme catalytic alpha and beta subunits (Palphabeta) is inhibited by two gamma subunits (Pgamma). Previous results have established that approximately 5-7 C-terminal residues of Pgamma comprise the inhibitory domain. To study the interaction between the Pgamma C-terminal region and Palphabeta, the Pgamma mutant (Cys68 --> Ser, and the… CONTINUE READING
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