The gH-gL complex of herpes simplex virus (HSV) stimulates neutralizing antibody and protects mice against HSV type 1 challenge.

@article{Peng1998TheGC,
  title={The gH-gL complex of herpes simplex virus (HSV) stimulates neutralizing antibody and protects mice against HSV type 1 challenge.},
  author={Tao Peng and Manuel Ponce-de-Le{\'o}n and Hualiang Jiang and Glenn Dubin and John M. Lubinski and Roselyn J Eisenberg and Gary H Cohen},
  journal={Journal of virology},
  year={1998},
  volume={72 1},
  pages={65-72}
}
The herpes simplex virus type 1 (HSV-1) gH-gL complex which is found in the virion envelope is essential for virus infectivity and is a major antigen for the host immune system. However, little is known about the precise role of gH-gL in virus entry, and attempts to demonstrate the immunologic or vaccine efficacy of gH and gL separately or as the gH-gL complex have not succeeded. We constructed a recombinant mammalian cell line (HL-7) which secretes a soluble gH-gL complex, consisting of gH… CONTINUE READING