The fuzzy math of solid tumor stem cells: a perspective.

  title={The fuzzy math of solid tumor stem cells: a perspective.},
  author={Scott E. Kern and Darryl Shibata},
  journal={Cancer research},
  volume={67 19},
Apparently effective therapeutic agents very often fail to cure cancer patients. It is therefore attractive to wonder whether a specific resistant cell subset should be recognized and separately targeted. In solid tumors, such as carcinomas, a minor population of "cancer stem cells" has been proposed and sought experimentally in human tumors and isolated cell populations. It is often overlooked that the rationale and supportive data are essentially numerical and can be evaluated as such. A… CONTINUE READING