Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges
- Biology, MedicineInternational journal of molecular sciences
Schizophrenia (SZ) is a heritable brain disease originating from a complex interaction of genetic and environmental factors. The genes underpinning the neurobiology of SZ are largely unknown but…
Strategies for integrated analysis in imaging genetics studies
- Computer Science, MedicineNeuroscience & Biobehavioral Reviews
A Bayesian predictive model for imaging genetics with application to schizophrenia
- Computer Science
This work proposes an integrative Bayesian risk prediction model that allows us to discriminate between individuals with schizophrenia and healthy controls, based on a sparse set of discriminatory regions of interest (ROIs) and SNPs.
A review of multivariate analyses in imaging genetics
- Computer Science, MedicineFront. Neuroinform.
A survey of recent publications using data from neuroimaging and genetics, focusing on methods capturing multivariate effects accommodating the large number of variables from both imaging data and genetic data, and a recently proposed method known as independent vector analysis are surveyed.
Neurodevelopmental model of schizophrenia: update 2012
- Psychology, MedicineMolecular Psychiatry
This selective review updates the 2005 review of recent studies that have impacted, or have the greatest potential to modify or extend, the neurodevelopmental model of schizophrenia, and suggests that placental pathology could be a key measure in future prenatal high-risk studies.
From gene to disorder in ADHD: Mapping mechanisms at different levels of complexity
Among other findings, it is able to show that ADHD and the intracranial volume are significantly negatively correlated at the global genetic level, resembling earlier phenotypic observations.
A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology
- Psychology, MedicineMolecular Psychiatry
This review showcases techniques and developments that address the challenges of conducting research on individual variables with small effects, absence of detailed mechanisms, and a need to translate findings toward greater clinical relevance and highlights the benefits of a neurogenetics approach to understanding brain, behavior and psychopathology.
Associations between brain abnormalities and common genetic variants for schizophrenia: a narrative review of structural and functional neuroimaging findings.
- MedicineAnnals of palliative medicine
A summary of current progress in neuroimaging findings to detect genetic variants that may influence the brain's structure and function, and thus improve understanding of how this interaction affects the onset of schizophrenia is provided.
Behavior genetics: Past, present, future
- Psychology, MedicineDevelopment and Psychopathology
Behavior genetics has made significant contributions to developmental psychopathology by documenting the interplay among risk and protective factors at multiple levels of the organism, by clarifying the causal status of risk exposures, and by identifying factors that account for change and stability in psychopathology.
SHOWING 1-10 OF 75 REFERENCES
Imaging genetics: Progressing by leaps and bounds
- Medicine, BiologyNeuroImage
The need for an explanatory framework has lead to the development of novel research strategies such as imaging genetics, which will be the focus of this special issue.
- MedicineBritish medical bulletin
All of these biological relationships have been revealed in relatively small samples of healthy volunteers and in the absence of observable differences at the level of behaviour, underscoring the power of a direct assay of brain physiology like fMRI in exploring the functional impact of genetic variation.
From maps to mechanisms through neuroimaging of schizophrenia
- Psychology, MedicineNature
Characterizing the neural risk architecture of schizophrenia provides a translational research strategy for future treatments and defines neural systems that mediate heritable risk linked to candidate and genome-wide-supported common variants.
The endophenotype concept in psychiatric genetics
- Biology, MedicinePsychological Medicine
A review of the genetic architecture of traits in model organisms provides no support for the view that the effect sizes of loci contributing to phenotypes closer to the biological basis of disease is any larger than those contributing to disease itself.
Intermediate phenotypes in psychiatric disorders.
- Biology, MedicineCurrent opinion in genetics & development
Intermediate or brainless phenotypes for psychiatric research?
- Medicine, PsychologyPsychological Medicine
It is argued that, while not all intermediate phenotypes are created equal, the hypothesis-driven investigation of the translational cascades linking genetic variation to disturbed behavior is a viable and important strategy that should not be supplanted by an exclusive focus on brainless, clinical/categorical phenotypes investigated in very large numbers of participants.
Common variants conferring risk of schizophrenia
- Biology, MedicineNature
Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
The endophenotype concept in psychiatry: etymology and strategic intentions.
- Psychology, MedicineThe American journal of psychiatry
The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
- Biology, MedicineScience
These findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.