The future of epigenetic therapy in solid tumours—lessons from the past

@article{Azad2013TheFO,
  title={The future of epigenetic therapy in solid tumours—lessons from the past},
  author={Nilofer Saba Azad and Cynthia A. Zahnow and Charles M Rudin and Stephen B. Baylin},
  journal={Nature Reviews Clinical Oncology},
  year={2013},
  volume={10},
  pages={256-266}
}
The promise of targeting epigenetic abnormalities for cancer therapy has not been realized for solid tumours, although increasing evidence is demonstrating its worth in haematological malignancies. In fact, true clinical efficacy in haematopoietic-related neoplasms has only become evident at low doses of epigenetic-targeting drugs (namely, inhibitors of histone deacetylase and DNA methyltransferases). Describing data from preclinical studies and early clinical trial results, we hypothesize that… CONTINUE READING
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