The future of association studies: gene-based analysis and replication.

@article{Neale2004TheFO,
  title={The future of association studies: gene-based analysis and replication.},
  author={Benjamin M. Neale and Pak Chung Sham},
  journal={American journal of human genetics},
  year={2004},
  volume={75 3},
  pages={
          353-62
        }
}
Historically, association tests were limited to single variants, so that the allele was considered the basic unit for association testing. As marker density increases and indirect approaches are used to assess association through linkage disequilibrium, association is now frequently considered at the haplotypic level. We suggest that there are difficulties in replicating association findings at the single-nucleotide-polymorphism (SNP) or the haplotype level, and we propose a shift toward a gene… CONTINUE READING

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